| 脂肪干细胞的研究进展 |
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| 引用本文： | 周瑞平[综述],陈志英,李容林[审校].脂肪干细胞的研究进展[J].医学综述,2013(21):3860-3862. |
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| 作者姓名： | 周瑞平[综述] 陈志英 李容林[审校] |
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| 作者单位： | [1]中山大学光华口腔医学院,广州510060 [2]中国科学院深圳先进技术研究院基因中心,广东深圳518055 |
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| 摘 要： | 脂肪源性间充质干细胞（ADSCs）是从脂肪组织中分离得到的一种成体干细胞，简称脂肪干细胞，它和骨髓间充质干细胞一样，具有自我更新和多向分化潜能，在体外各种诱导条件下可分化为成骨、软骨、脂肪、肌肉、神经、肝和内皮等细胞。脂肪组织在体内含量多、获得容易、创伤小，且ADSCs具有数量多、增殖能力强、可以自体移植等优势，有望成为组织工程理想的种子细胞，在基因治疗、细胞移植等方面具有广泛的应用前景。
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| 关 键 词： | 脂肪干细胞 间充质干细胞 组织工程 基因治疗 |
Research Progress in Adipose-derived Stem Cells |
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| Institution: | ZHOU Rui-ping , CHEN Zhi-ying , LI Rong-lin. (1. Guanghua School of Stomatology Affiliated to Sun Yet-sen University, Guangzhou 510060, China; 2. Center for C-ene and Cell Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ) |
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| Abstract: | Adipose-derived mesenchymal stem ceils （ADSCS） is a kind of adult stem cells, from the adipose tissue. Similar to bone marrow mesenchymal stem cells, it holds the potentials of self-renewal and multi-lineage differentiation. In the presence of lineage-specific induction factors, ADSCS are capable of differentiating into osteogenic, ehondrogenic, adipogenic, myogenic, neurogenic, hepatic and endothelial cells in vitro. Due to the advantages of easy-getting, small trauma, high quantity, ADSCs are expected to become an ideal seeding cell for tissue engineering,with a broad applications in gene therapy and cell transplantation. |
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| Keywords: | Adipose-derived stem cells Mesenchymal stem cells Tissue engineering Gene therapy |
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