A randomized comparison of immediate versus delayed application of G-CSF in induction therapy for patients with acute myeloid leukemia unfit for intensive chemotherapy |
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| Authors: | von Lilienfeld-Toal Marie Hahn-Ast Corinna Kirchner Hartmut Flieger Dimitri Dölken Gottfried Glasmacher Axel |
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| Affiliation: | Medizinische Klinik und Poliklinik I, Universit?tsklinikum Bonn, Sigmund-Freud Str. 25, 53105 Bonn. m.lilienfeld.toal@uni-bonn.de |
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| Abstract: | We randomized 66 elderly patients with AML unfit for conventional chemotherapy to receive GCSF from d6 or from d12 after induction-chemotherapy with cytarabine/idarubicin. There was no difference in duration of neutropenia (17 days vs. 19 days, p=0.67) or rate of complications. Delayed treatment can reduce the administration of G-CSF without adverse consequences. |
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