鼻咽癌尿激酶型纤溶酶原激活物及VEGF 表达与侵袭转移关系

 目的　探讨鼻咽癌 ( NPC)组织尿激酶型纤溶酶原激活物 ( u PA)及血管内皮细胞生长因子 ( VEGF)表达与癌生物学行为的关系。方法　采用免疫组织化学方法检测了 45例 NPC组织中的 u PA及 VEGF表达。结果　NPC有淋巴结转移组 u PA及 VEGF的阳性率较无淋巴结转移组高 ,复发或远处转移组与无复发组之间有显著性差异 ;u PA与 VEGF表达有相关性 ( P<0 .0 5 )。结论　u PA与 VEGF与鼻咽癌的浸润及转移密切相关 ,在鼻咽癌的发生、发展和转移过程中可能起促进作用.

Expression of uPA and VEGF:Association with Invasion and Metastasis in Nasopharyngeal Carcinoma

Objective To investigate the relationship between expression of uPA (urokinase type plasmiongen activator,uPA)and VEGF(Vascular endothelial growth factor,VEGF)and invasion and metastasis of nasopharyngeal carcinoma (NPC).Methods Expression of uPA and VEGF using immunohistochemical LASB stainning,Paraffin embedded specimens of 45 patients with NPC were detected.All ptients were folowed up 3 years.Results The positive rate of uPA and VEGF were significantly higher in cases with recurrence (R NPC) and in cases with lymph node involvement (LN ) than those without recurrence(NR NPC)or lymph node involvement(LN );expressions of uPA had positive correlated with VEGF.Conclusion uPA and VEGF are closely correlated with invasion and metastasis of NPC,which may contribute to tumor development,invasion and metastasis.