Transcapillary exchange and retention of fluoride,strontium, EDTA,sucrose, and antipyrine in bone

Summary The extractions of⁸⁵Sr²⁺,¹⁸F⁻, sucrose-¹⁴C, EDTA-⁵¹Cr, and antipyrine-¹⁴C in bone were determined by the multiple indicator-dilution method. Fluoride and strontium extractions were 18 to 70% during a single transcapillary passage, and those of EDTA and sucrose were from 11 to 59%, whereas extraction of antipyrine was 87%. Injections of⁸⁵Sr²⁺ and¹⁸F⁻ made when perfusion was done alternately with blood and plasma resulted in similar fractional extractions. When flow and extraction were measured simultaneously, extraction was related inversely to flow.