健骨颗粒对去卵巢大鼠骨质疏松症预防作用的研究

目的：探讨健骨颗粒对实验性I型原发性骨质疏松症的预防作用。方法：运用切除大鼠卵巢方法建立去卵巢骨质疏松症模型，采用双能X线骨密度测定法和放射免疫分析法等，检测实验鼠骨骼密度、血清骨钙素、雌二醇、降钙素水平以及子宫指数。结果：健骨颗粒可明显升高骨密度和子宫指数，提高血清雌二醇、降钙素水平，降低骨钙素含量。结论：健骨颗粒可通过调节机体相关内分泌功能，有效协调钙调节激素，降低骨的转换率，增加骨密度，对I型原发性骨质疏松有预防或延缓发生的作用。

Study on Preventive Effect of Jiangu Granule on Osteoporosis in Ovariectomized Rats

OBJECTIVE: To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I. METHODS: Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also. RESULTS: JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level. CONCLUSION: JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.