健骨颗粒对去卵巢大鼠骨质疏松症预防作用的研究 |
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引用本文: | 林燕萍,马建华,冯尔宥,黄美雅.健骨颗粒对去卵巢大鼠骨质疏松症预防作用的研究[J].中国中西医结合杂志,2002,22(5):369-371. |
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作者姓名: | 林燕萍 马建华 冯尔宥 黄美雅 |
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作者单位: | 福建中医学院骨伤系,福州,350003 |
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基金项目: | 福建省自然科学基金重大项目(No.C9830001),教育部骨干教师资助计划项目(No.1946) |
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摘 要: | 目的:探讨健骨颗粒对实验性I型原发性骨质疏松症的预防作用。方法:运用切除大鼠卵巢方法建立去卵巢骨质疏松症模型,采用双能X线骨密度测定法和放射免疫分析法等,检测实验鼠骨骼密度、血清骨钙素、雌二醇、降钙素水平以及子宫指数。结果:健骨颗粒可明显升高骨密度和子宫指数,提高血清雌二醇、降钙素水平,降低骨钙素含量。结论:健骨颗粒可通过调节机体相关内分泌功能,有效协调钙调节激素,降低骨的转换率,增加骨密度,对I型原发性骨质疏松有预防或延缓发生的作用。
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关 键 词: | 骨质疏松症 预防 健骨颗粒 骨密度 内分泌激素 子宫指数 实验研究 |
修稿时间: | 2001年11月5日 |
Study on Preventive Effect of Jiangu Granule on Osteoporosis in Ovariectomized Rats |
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Authors: | LIN Yan ping MA Jian hu FENG Er you |
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Abstract: | OBJECTIVE: To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I. METHODS: Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also. RESULTS: JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level. CONCLUSION: JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD. |
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Keywords: | osteoporosis prevention Jiangu granule bone mineral density hormone uterus index |
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