新型螯合剂H-73-10的毒性实验

小鼠腹腔注射新型螯合剂H-73-10的LD_{50(5)为7.05克/公斤。以1/4LD50(5)的剂量给同种小鼠腹腔注射, 每天1次, 连续7天, 停药24小时后, 测得LDs㈣, 为7.09克/公斤, 表明无蓄积毒性。大鼠腹腔注射LD50(5)为3.6克/公斤比小鼠低。大鼠、狗和猴的亚急性毒性实验结果表明。药物局部刺激反应与浓度有关。大剂量给药, 胃肠道有一定反应。对外周血、肝、肾功能、血钙、血磷含量影响不大。病理学检查在肾脏近曲管上皮细胞胞浆内见有可逆性褐色颗粒沉着, 并伴有空泡晕。实验结果表明H-73-10的毒性比较低}

Toxicity Study of a New Chelating.Agent H-73-10

The acute toxicity teats of a new chelating agent H-73-10 have been performed. Mice werc intxapcritoneally injected with this agent and its LD_{50(5) was found to be 7.05g/kg.The salve strain of mice were geven a dose of i14 LD50(5)v onec a day for successive seven days.Twenty-four hours after the last injection, the LD50(5) was found tobe 7.09g/kg;therefore.Ithasno cumulative toxicity.Its LD50(5) in rats was found to be 3.6g/kg, which is much lower than that in mice. The tests for its subacutc toxicity in rats, dogs, and monkeys demonstrated that an irritative reaction caused by thelocal concenutration of the agent was found at the injection sites.There were some gastrointestinal reactionsinthe animals of hizh dose group, while there were no obvious effects upon peripheral blood, hepatic and renal functions, and blood calcium and phosphorus contents. Pathological examination revealed brown pigment granules and vacuoles in the protoplasm of epithelial cells of the proximal convoluted Ieral, tubules, and toth of them were reversible.These experiments confirmed that this new chelating agent is of low toxicity.}