缩宫素与男性性功能

缩宫素是一种女性激素,其主要功能是参与子宫收缩及乳汁排泄。但是近年来发现,缩宫素参与多种中枢及外周信号通路,主要调控生殖生理及生殖行为,包括男性生殖及性行为。缩宫素对于阴茎勃起功能的调控是双向的,在中枢是促进而在海绵体内则抑制阴茎勃起,也参与射精及射精后阴茎疲软,以及射精后阴茎长久不应期。中枢性缩宫素及其受体可作为开发治疗阴茎勃起功能障碍药物的新靶点,而缩宫素海绵体内注射可望成为治疗阴茎异常勃起的有效药物之一。本文综述缩宫素在男性性功能方面的作用。

Oxytocin and male sexual function

Oxytocin(OT) is a female hormone with the main function of facilitating uterine contraction and milk ejection.Recent studies show that OT is involved in multiple signaling pathways in the central and peripheral nerve system and mainly regulates the physiology and activity of reproduction,including male reproduction and sexual behavior.The roles of OT in penile erection are bio-phasic with proerectile effect in the central nerve system while peripherally inhibiting erection.OT also mediates ejaculation,post-...