| 用位置偏爱法评价二氢埃托啡的精神依赖性潜力 |
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| 引用本文： | 王年生,邓红兵,蔡志基.用位置偏爱法评价二氢埃托啡的精神依赖性潜力[J].中国药物依赖性杂志,1993(4). |
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| 作者姓名： | 王年生 邓红兵 蔡志基 |
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| 作者单位： | 北京医科大学中国药物依赖性研究所，北京医科大学中国药物依赖性研究所，北京医科大学中国药物依赖性研究所 北京 100083，北京 100083，北京 100083 |
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| 摘 要： | 本文报道应用条件性位置偏爱法,研究了DHE的精神依赖性的潜力及其与受体的关系。结果表明,DHE在1倍镇痛ED_(50)的剂量0.6μg·kg~(-1)sc下,就可产生明显的位置偏爱,且偏爱程度随药物剂量增加(3倍ED_(50),9倍ED_(50))而加强。但是DHE产生偏爱的受体机制可能与Mor不同,它不为M_(5050)(3 mg·kg~(-1)ip)所阻断。这些结果说明,DHE有较强的精神依赖潜力,而且在形成机制上,有其独特之处。
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| 关 键 词： | 二氢埃托啡 吗啡 精神依赖性 条件性位置偏爱 |
DIHYDROETORPHINE IN CONDITIONED PLACE PREFERENCE |
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| WANG Nian-Sheng,DENG Hong-Bing,CAI Zhi-Ji.DIHYDROETORPHINE IN CONDITIONED PLACE PREFERENCE[J].Chinese Journal of Drug Dependence,1993(4). |
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| Authors: | WANG Nian-Sheng DENG Hong-Bing CAI Zhi-Ji |
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| Abstract: | We have studied the psychological dependence potential of DHE by using conditioned place preferance(CPP) paradigm in mice. Our data showed that at the dose of 0.6μg . kg~(-1) (ED_(50) of hot-plate method) sc, DHE produced a significant place preference and this preference was potentiated by increasing dose to 3 ED_(50)and 9 ED_(50). Aparently different from morphine, the preference of DHE could not be blocked by diprenorphine (3 mg . kg~(-1) ip). These results suggested that DHE be of relatively high psychological de- pendence potential and its machenism may be unique. |
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| Keywords: | dihydoretrophine morphine psychological dependence conditioned place preferance |
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