能谱 CT联合 VEGF预测 120例肝癌 TACE术后碘油沉积

目的 探究能谱CT定量分析联合血清血管内皮生长因子(VEGF)水平检测在肝癌经导管肝动脉化疗栓塞术(TACE)后碘油沉积中的预测价值。方法 收集2020年1月至2022年3月三门峡市中心医院行TACE术的120例肝癌病人作为研究对象，并将其分为A组(TACE术后碘油沉积面积>50%)和B组(TACE术后碘油沉积面积≤50%)；同时分为C组(TACE术后碘油沉积区)和D组(TACE术后无碘油沉积区)。采用能谱CT检测肝癌病人TACE术前碘浓度及术后碘油沉积情况，计算动脉期标准化碘浓度(ANIC)、静脉期标准化碘浓度(VNIC)、肝脏标准化碘浓度比率(ICratio,ICratio=ANIC/VNIC)，采用酶联免疫吸附法检测血清VEGF水平；绘制ROC曲线分析术前碘浓度及血清VEGF水平预测肝癌TACE术后碘油沉积情况的价值；采用多因素logistic回归分析肝癌TACE术后碘油沉积情况的影响因素。结果 B组与A组肿瘤分期Ⅲ+Ⅳ期(60.29%比19.23%)、组织低分化(47.06%比23.08%)、血管侵犯(63.24%比11.54%)比例及ANIC(0.18±0.06比0.2...

Application of spectral CT combined with VEGF in predicting lipiodol deposition afterTACE for 120 cases of liver cancer

Objective To explore the predictive value of spectral CT quantitative analysis combined with serum vascular endothelialgrowth factor (VEGF) detection for lipiodol deposition after transcatheter arterial chemoembolization (TACE) for liver cancer. Meth? ods A total of 120 patients with liver cancer who underwent TACE in Sanmenxia Central Hospital from January 2020 to March 2022were enrolled and assigned into group A (area of lipiodol deposition after TACE >50%) and group B (area of lipiodol deposition afterTACE ≤50%); meanwhile, they were assigned into group C (with lipiodol deposition after TACE) and group D (without lipiodol deposi?tion after TACE). Spectral CT was used to detect preoperative iodine concentration and postoperative lipiodol deposition in patientswith liver cancer undergoing TACE, and the arterial-phase normalized iodine concentration (ANIC), the venous-phase normalized io? dine concentration (VNIC) and the liver-normalized iodine concentration ratio (ICratio, ICratio=ANIC/VNIC) were calculated; ELISAwas used to detect serum VEGF level. ROC curve was drawn to analyze the value of preoperative iodine concentration and serum VEGFlevel in predicting lipiodol deposition after TACE for liver cancer; multivariate logistic regression was used to analyze the influencingfactors of lipiodol deposition after TACE for liver cancer.Results There were statistically significant differences between group B and group A in cancer staging Ⅲ+Ⅳ (60.29% vs. 19.23%), poor differentiation (47.06% vs. 23.08%), vascular invasion ratio (63.24% vs. 11.54%), and levels of ANIC (0.18±0.06 vs. 0.26±0.08), VNIC (0.40±0.10 vs. 0.54±0.12), and serum VEGF [(284.56±78.17) ng/L vs. (225.74±61.05) ng/L] (P<0.05). VEGF and histological differentiation were the influencing factors for area of lipiodol deposition ≤50% at 1 month after TACE for liver cancer (P<0.05). There were statistically significant differences in ANIC (0.15±0.04 vs. 0.24±0.07), VN? IC (0.44±0.09 vs. 0.53±0.10) and ICratio (0.34±0.08 vs. 0.45±0.09) between group D and group C (P<0.05).Conclusion Spectral CTquantitative analysis combined with serum VEGF detection can better predict the lipiodol deposition after TACE for liver cancer.