二苯并氮杂䓬类化合物的药理作用研究进展

二苯并氮杂䓬类化合物是一种重要的含氮杂环类化合物。结构修饰不仅可对二苯并氮杂䓬类化合物中心七元环环上氮原子进行改造，也可在两边的苯环上连接不同基团，不同取代基对其活性影响也不同。二苯并氮杂䓬类化合物具有心脏保护作用、血管性认知障碍保护作用、抗抑郁作用、抗焦虑作用、抗癫痫作用、降糖作用、抗癌作用、抗炎作用、抗氧化作用和镇痛作用。总结了二苯并氮杂䓬类化合物的药理作用研究进展，以期为设计合成二苯并氮杂䓬类药物及其潜在药理活性提供参考。

Research progress on pharmacological effects of dibenzodiazepines

Dibenzodiazepines are an important class of heterocyclic compounds. Structural modification of dibenzodiazepines can not only modify the nitrogen atom in the central seven-membered ring, but also connect other substituent groups to the benzene ring on both sides, and different substituents have different activities for it. Dibenzodiazepines have a wide range of pharmacological activities, including cardioprotective effects, vascular cognitive impairment protective effects, anti-depression, anti-anxiety effects, anti-epilepsy, hypoglycemic effects, anticancer effects, anti-inflammatory effects, antioxidant effects, and analgesic effects. This article summarizes the research progress on the pharmacological effects of dibenzoazepines, with the aim of providing reference for the design, synthesis, and potential pharmacological activities of dibenzoazepine drugs.