| 人体主动脉瓣膜钙化组织的力学性质 |
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| 引用本文： | 杨贤达,冯文韬,刘琨,张海波,姚杰,冯成龙,王丽珍,樊瑜波. 人体主动脉瓣膜钙化组织的力学性质[J]. 医用生物力学, 2021, 36(5): 747-750 |
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| 作者姓名： | 杨贤达 冯文韬 刘琨 张海波 姚杰 冯成龙 王丽珍 樊瑜波 |
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| 作者单位： | 北京航空航天大学 生物力学与力生物学教育部重点实验室，北京市生物医学工程高精尖创新中心，生物与医学工程学院;首都医科大学附属安贞医院 心外科 |
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| 基金项目： | 国家重点研发计划（2017YFB0702500），北京自然科学基金项目（7194287），科技部创新人才推进计划重点领域创新团队（11421201），国家重大科研仪器设备研制专项（11827803） |
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| 摘 要： | 目的采用纳米压痕测试方法,测量人体主动脉瓣取出物的钙化组织的材料力学性能。方法采集5名主动脉瓣狭窄患者的瓣叶取出物,选取钙化瓣叶进行纳米压痕测试,获得钙化组织弹性模量、硬度等材料力学参数。结果瓣叶钙化组织的弹性模量为(15.69±3.89) GPa,硬度为(0.59±0.15) GPa。结论通过纳米压痕测试方法得到瓣叶钙化组织的弹性模量和硬度,为瓣膜的生物力学研究提供实验数据参考。
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| 关 键 词： | 主动脉瓣； 瓣叶； 钙化组织； 纳米压痕； 弹性模量 |
| 收稿时间： | 2020-10-30 |
| 修稿时间： | 2021-01-18 |
Mechanical Properties of Calcification from Human Aortic Valve |
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| YANG Xiand,FENG Wentao,LIU Kun,ZHANG Haibo,YAO Jie,FENG Chenglong,WANG Lizhen,FAN Yubo. Mechanical Properties of Calcification from Human Aortic Valve[J]. Journal of Medical Biomechanics, 2021, 36(5): 747-750 |
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| Authors: | YANG Xiand FENG Wentao LIU Kun ZHANG Haibo YAO Jie FENG Chenglong WANG Lizhen FAN Yubo |
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| Affiliation: | Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University;Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University |
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| Abstract: | Objective To measure mechanical properties of calcified tissues from human aortic valve by nanoindentation test. Methods Leaflets from 5 patients with aortic stenosis were collected. Elastic modulus and hardness of the calcified leaflets were obtained by nanoindentationtest. Results The elastic modulus and hardness of the calcified leaflets were (15.69±3.89) GPa and (0.59±0.15) GPa, respectively. Conclusions The elastic modulus and hardness of the calcified valve tissues can be obtained by nanoindentationtest, which provides experimental data for biomechanical research of the valve. |
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| Keywords: | aortic valve leaflets calcification nanoindentation elastic modulus |
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