Cigarette Smoke Ventilation Decreases the Contractile Responses of Intestinal Smooth Muscle

Abstract: Hamster stomach strips or isolated rat colons were superfused by the effluent from isolated hamster or rat lungs, respectively. Cigarette smoke ventilation of the lungs caused a decrease in the contractile responses of hamster stomach strips to prostaglandin E₂ and of rat colons to angiotensin II, when Krebs buffer was used as perfusion medium. On rat colons, diluted blood was as effective carrier of the inhibitory compounds as was the buffer solution.