| 炎症介质在干眼发病机制中的作用和抗炎治疗进展 |
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| 引用本文： | 丁宁,邓伟民,高卫萍.炎症介质在干眼发病机制中的作用和抗炎治疗进展[J].国际眼科杂志,2021,21(11):1881-1886. |
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| 作者姓名： | 丁宁 邓伟民 高卫萍 |
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| 作者单位： | 中国江苏省南京市,南京中医药大学附属医院眼科; 中国江苏省南京市,南京大学医学院附属鼓楼医院眼科,中国江苏省南京市,东南大学附属中大医院,中国江苏省南京市,南京中医药大学附属医院眼科 |
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| 基金项目： | 国家自然科学基金项目(No.81774419) |
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| 摘 要： | 干眼作为多因素引起的复杂疾病，其发病机制也复杂多样，目前认为泪膜不稳定、泪液渗透压升高、眼表炎性和神经异常等为干眼公认的发病机制，并且炎症作为干眼生理病理发病的关键机制被得到证实，为了更全面地了解干眼的炎症级联反应，此次重点讨论与干眼相关的关键因子和细胞介质的作用以及相关抗炎治疗。
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| 关 键 词： | 干眼 炎症 炎症介质 抗炎治疗 |
| 收稿时间： | 2021/3/10 0:00:00 |
| 修稿时间： | 2021/9/18 0:00:00 |
Role of inflammatory mediators in the pathogenesis and the progress of anti-inflammatory treatment of dry eye |
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| Ning Ding,Wei-Min Deng and Wei-Ping Gao.Role of inflammatory mediators in the pathogenesis and the progress of anti-inflammatory treatment of dry eye[J].International Journal of Ophthalmology,2021,21(11):1881-1886. |
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| Authors: | Ning Ding Wei-Min Deng and Wei-Ping Gao |
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| Institution: | Department of Ophthalmology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China; Department of Ophthalmology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China,Zhongda Hospital, Southeast University, Nanjing 210029, Jiangsu Province, China and Department of Ophthalmology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China |
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| Abstract: | Dry eye is a complex disease caused by multiple factors which pathogenesis is complex and diverse. At present, the tear film instability, the increase of tear osmotic pressure, ocular surface inflammation and neurological abnormalities are recognized as the pathogenesis of dry eye. Particularly, inflammation has been confirmed as the key mechanism for the pathogenesis of the dry eye. In this case, this study focuses on discussing the role of critical factors and cell mediators related to dry eye and the anti-inflammatory treatments for it to understand the inflammatory cascade of the dry eye more comprehensively. |
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| Keywords: | dry eye inflammation inflammatory mediators anti-inflammatory treatment |
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