某三级甲等医院干预前后住院患者的抗菌药物使用强度分析

目的:了解某三级甲等医院开展抗菌药物临床应用专项整治活动前、后住院患者抗菌药物使用强度(AUD)的变化情况。方法:回顾性调查该院2010年12月-2011年5月(整治前)和2011年6-11月(整治后)住院患者抗菌药物的使用品种、品规,计算其AUD,并进行对比分析。结果:整治后该院抗菌药物品种、品规从整治前的75种、144个分别下降至48种、79个;抗菌药物的AUD由整治前的85.6DDDs/100人/天下降为56.8DDDs/100人/天;静脉用药的AUD由整治前的73.3DDDs/100人/天下降至49.4DDDs/100人/天;排序前10位药品的AUD由整治前的54.0DDDs/100人/天下降至44.5DDDs/100人/天。结论:通过开展抗菌药物临床应用专项整治活动,抗菌药物的AUD、品种、品规降幅较大,但抗菌药物特别是β-内酰胺类复方制剂的AUD仍较高,还须进一步加强干预和控制抗菌药物的使用。

Analysis of Antibiotics Use Density in a Third-grade Class-A Hospital before and after Intervention

OBJECTIVE： To understand the change of antibiotics use density （AUD） in the inpatients of a third-grade class-A hospital before and after intervention. METHODS： The utilization of antibiotics in the hospital during Dec. 2010- May 2011 （be- fore intervention） and Jun. 2011- Nov. 2011 （after intervention） was analyzed retrospectively in terms of varieties and specifica- tion. RESULTS： After intervention, the varieties and specification of antibiotics decreased from 75 varieties and 144 kinds to 48 va- rieties and 79 kinds; AUD of antibiotics decreased from 85.6 DDDs/100 persons/day to 56.8 DDDs/100 persons/day; AUD of intra- venous administration decreased from 73.3 DDDs/100 persons/day to 49.4 DDDs/100 persons/day; AUD of top 10 drugs decreased from 54.0 DDDs/100 persons/day to 44.5 DDDs/100 persons/day. CONCLUSION： Through developing special rectification of clini- cal use of antibiotics, the AUD, types and specification of antibiotics show great change, but AUD of Compound β-lactam still high, we should further intervene in and control use of antibiotics.