米非司酮与生化汤应用于中期妊娠引产的疗效比较

目的:比较米非司酮与生化汤对中期妊娠引产的疗效。方法:选取我院2009年1月-2011年7月300例中期妊娠引产的妊娠者,随机均分为米非司酮组和生化汤组,2组均应用利凡诺中期引产,米非司酮组于注射利凡诺后口服米非司酮75mg,qd,共服2d;生化汤组从手术当天起口服生化汤,每日1剂,共服5d。比较2组患者引产成功率、引产时间、阴道流血量、胎盘胎膜残留情况及并发症发生情况。结果:2组引产成功率及胎盘胎膜残留情况比较,差异无统计学意义(P>0.05);米非司酮组胎儿引出时间及总产程显著短于生化汤组,阴道流血量也少于生化汤组,2组比较差异均有统计学意义(P<0.05);生化汤组产后出血发生率显著低于米非司酮组(P<0.05)。2组均未见不良反应发生。结论:中期妊娠引产中应用米非司酮与生化汤引产成功率及胎盘胎膜残留情况无显著性差异,米非司酮相比生化汤可明显缩短引产时间,减少术中阴道流血量,但产后出血发生率较高。

Comparison of Efficacy of Mifepristone and Biochemical Soup in the Mid-pregnancy Abortion

OBJECTIVE： To compare mifepristone and biochemical soup in the mid-pregnancy abortion of labor in effect. METHODS： Our hospital from January 2009 to 2011 July, 300 cases of mid-term pregnancy, induced abortion patients were ran-domly divided into the mifepristone group and biochemical soup group, both group were application the rivanol medium-term abortion, mifepristone were given 2 days preoperative oral mifepristone （75 mg, 2 d）, the biochemical soup group at the injection day oral biochemical soup a day, 5d, 2 groups were compared abortion success rate, abortion time, the amount of vaginal bleeding, placental membranes, residual and complications situation. RESULTS： The 2 groups of successful abortion rate and the residue of the placental membranes, the difference was not statistically significant （P〉0.05） ; mifepristone group fetus leads to time and total process time was significantly shorter than the biochemical soup group, vaginal bleeding is less in the biochemical soup group, the differences were statistically significant .（P〈0.05） ; Biochemical soup of the incidence of postpartum hemorrhage was significantly lower than the mifepristone group （P〈0.05）. There was no ADR in 2 groups. CONCLUSION： Mifepristone and biochemical soup in the application of the united rivanol trimester pregnancy abortion, placental membranes residue and the rate of successful abortion, no difference in the mifepristone compared to the biochemical soup significantly shorten the abortion time and amount of vagi- nal bleeding in surgery , but the incidence of postpartum hemorrhage higher.