我院173例药品不良反应报告分析

目的:了解我院药品不良反应(ADR)发生的特点及规律。方法:对我院2009-2011年上报的173例ADR报告进行回顾性分析。结果:173例ADR报告中,新的严重的ADR占30.64%;门/急诊上报的ADR占29.48%;注射剂是引发ADR的主要剂型,占总例数的78.61%;抗菌药物引发的ADR占30.64%;在临床表现方面,以皮肤及其附件损害最常见,占42.77%。结论:临床应加强抗菌药物使用管理,ADR发生率高的药品应重点监测,以保证药物使用的安全、有效,促进临床合理用药。

Analysis of 173 Cases of ADR Reports in Our Hospital

OBJECTIVE： To investigate the characteristics and regularity of ADR in our hospital. METHODS： 173 ADR cases reported by our hospital during 2009--2011 were analyzed retrospectively. RESULTS： Of 173 ADR reports, new severe ADR ac- counted for 30.64% ; ADR reported by out-patient and emergency department accounted for 29.48% ; most of ADR were caused by injection, accounting for 78.61%; antibiotic-induced ADR accounted for 30.64%; main clinical manifestations were lesion of skin and appendants, accounting for 42.77%. CONCLUSION： Great importance should be attached to antibiotic management and moni- toring of drugs with high incidence of ADR to guarantee the safe and effective use of drugs in the clinic.