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槲皮素包合物微球的制备及其体外释放研究
引用本文:胡英,孙宝莹,高珊. 槲皮素包合物微球的制备及其体外释放研究[J]. 中国药房, 2012, 0(33): 3105-3107
作者姓名:胡英  孙宝莹  高珊
作者单位:[1]浙江医药高等专科学校,浙江宁波315100 [2]济南市中心医院神内科,济南250013
基金项目:宁波市科技局自然基金资助项目(2008A610095)
摘    要:目的:制备槲皮素β-环糊精包合物-壳聚糖微球(QT-CD-CM),并考察其理化性质和药物体外释放性能。方法:采用有机溶剂挥发法制备槲皮素β-环糊精包合物,再用乳化分散-离子交联法、以三聚磷酸钠为交联剂制备壳聚糖微球,并考察其形态、粒径、包封率、载药量和体外释放情况。结果:制备的QT-CD-CM形态规则、均质、无粘连,平均粒径(3.327±0.124)μm,包封率为32.4%,载药量为12.3%,在5%乙醇-磷酸盐缓冲液介质中72h可以达到完全释药,释药过程符合一级动力学模型。结论:QT-CD-CM理化性质及体外释药性能良好,制备工艺简单,有望成为理想的槲皮素给药系统。

关 键 词:槲皮素  包合物  壳聚糖  微球  制备  体外释放

Study on the Preparation of Quercetin Inclusion Complex Microsphere and Its Drug Release in Vitro
HU Ying,GAO Shan. Study on the Preparation of Quercetin Inclusion Complex Microsphere and Its Drug Release in Vitro[J]. China Pharmacy, 2012, 0(33): 3105-3107
Authors:HU Ying  GAO Shan
Affiliation:(Zhejiang Pharmaceutical College,Zhejiang Ningbo 315100,China) SUN Bao-ying(Dept.of Neurology,Jinan Central Hospital,Jinan 250013,China)
Abstract:OBJECTIVE:To prepare Quercetin-β-cyclodextrin inclusion complex-chitosan microspheres(QT-CD-CM),and to investigate their physiochemical property and release characteristics in vitro.METHODS:The quercetin-β-cyclodextrin inclusion complexes were prepared by organic solvent evaporation methods,and then formed chitosan microspheres which were prepared using emulsion-linking technique with sodium tripolyphosphate as the cross-linker.The morphology,particle size,encapsulation efficiency,drug-loading amount and release kinetics of microspheres were investigated.RESULTS:Prepared QT-CD-CM were regular,discrete and uniform spheres with mean particle size of(3.327±0.124) μm,encapsulation efficiency of 32.4% and drug-loading amount of 12.3%.Prepared microspheres released completely in 5% ethanol-PBS in 72 h,which was in line with first-order kinetic model.CONCLUSION:QT-CD-CM are sound in physicochemical and release property and simple in preparation technology,and can be used as ideal drug delivery system for quercetin.
Keywords:Quercetin  Inclusion complex  Chitosan  Microsphere  Preparation  In vitro release
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