| 楤木皂苷胶囊成型工艺辅料筛选 |
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| 引用本文： | 翁琰,奚苗苗,潘澄,崔佳,周丹,陆杨,窦芳,文爱东. 楤木皂苷胶囊成型工艺辅料筛选[J]. 中国药房, 2012, 0(35): 3291-3293 |
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| 作者姓名： | 翁琰 奚苗苗 潘澄 崔佳 周丹 陆杨 窦芳 文爱东 |
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| 作者单位： | [1]第四军医大学第一附属医院药剂科,西安710032 [2]西安力邦医药科技有限责任公司,西安710076 [3]陕西中医学院药学院,陕西咸阳712083 |
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| 基金项目： | 国家自然科学基金资助项目（81001673）;陕西省“13115”科技创新工程重大科技专项项目（2010ZDKG-62）;陕西省自然科学基础研究计划项目（2010JQ4018）. |
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| 摘 要： | 目的:优选楤木皂苷胶囊的成型工艺辅料。方法:以颗粒的成型合格率、吸湿百分率、休止角和堆密度为评价指标,在逐一单个筛选辅料的基础上,筛选出适合制备楤木皂苷胶囊的混合辅料,并考察临界相对湿度(CRH)。结果:微晶纤维素-乳糖(1:1,m/m)混合辅料制成的颗粒抗潮性能强,流动性好。CRH为78%。结论:所选辅料可用于制备楤木皂苷胶囊。
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| 关 键 词： | 楤木皂苷胶囊 成型工艺 吸湿率 休止角 堆密度 临界相对湿度 |
Selection of Excipients for Forming Technology ofAralia taibaiensis Saponin Capsules |
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| WENG Yan,XI Miao-miao,ZHOU Dan,LU Yang,DOU Fang,WEN Ai-dong. Selection of Excipients for Forming Technology ofAralia taibaiensis Saponin Capsules[J]. China Pharmacy, 2012, 0(35): 3291-3293 |
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| Authors: | WENG Yan XI Miao-miao ZHOU Dan LU Yang DOU Fang WEN Ai-dong |
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| Affiliation: | (Dept. of Pharmacy, The First Affil- iated Hospital of Fourth Military Medical University, Xi＇ an 710032, China) PAN Cheng (Xi＇ an Libang Pharmaceutical Technology Co., Ltd., Xi＇ an 710076, China) CUI Jia(College of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Shaanxi Xianyang 712083, China) |
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| Abstract: | OBJECTIVE： To optimize the excipients for forming technology of Aralia taibaiensis saponin capsules. METH- ODS： Using the shaping ratio, percentage of moisture absorption, angle of repose and bulk density of the granules as indexes, the suitable mixed excipient of A. taibaiensis capsules was selected through screening single excipient one by one. Critical relative hu- midity （RH）was studied. RESULTS： The granules made of microcrystalline cellulose and lactose with the proportion of 1 ： 1 （m/m） were moisture-resistant and had a good fluidity. CRH was 78%. CONCLUSION： The excipient in the study can be used for the preparation ofA. taibaiensis saponin capsules. |
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| Keywords: | Aralia taibaiensis saponin capsules Forming technology Percentage of moisture absorption Angle of repose Bulk density Critical relative humidity |
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