Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: A case report |
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| Authors: | MASAHIKO KIMURA MD KUNIO YOSHINO MD YUKINORI MAEOKA MD NORIKO SUZUKI MD |
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| Affiliation: | Department of Pediatrics, National Nishitottori Hospital, Mitsu, Tottori, Japan |
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| Abstract: | Abstract The case of a patient who developed thrombocytopenia during treatment with carbamazepine (CBZ) is described. The platelet count recovered soon after discontinuation of CBZ. Lymphocyte stimulation test with carbamazepine-10,11-epoxide (CBZ-10,11-EPOX), a major metabolite of CBZ, was positive, although with CBZ it was negative. These findings suggest that CBZ-10,11-EPOX was possibly causative in the pathogenesis of CBZ-induced thrombocytopenia in this case. |
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| Keywords: | carbamazepine carbamazepine-10 11-epoxide lymphocyte stimulation test thrombocytopenia. |
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