Cytotoxic oxylipins from a marine sponge Topsentia sp |
| |
Authors: | Luo Xuan Li Famei Hong Jongki Lee Chong-O Sim Chung Ja Im Kwang Sik Jung Jee H |
| |
Affiliation: | College of Pharmacy, Pusan National University, Busan 609-735, Korea. |
| |
Abstract: | By a bioactivity-guided fractionation, seven new oxylipins, topsentolides A(1)-C(2) (1-7), were isolated from the MeOH extract of a marine sponge Topsentia sp. Detailed NMR and MS analyses established the planar structures of these structurally related oxylipins, which are proposed to be biosynthesized by lipoxygenation followed by cyclization of unsaturated fatty acids. Acetonide derivatives and MTPA esters were prepared to elucidate the stereochemistry of topsentolides B(1) (3), B(2) (4), and C(2) (7). All compounds were tested against a panel of five human solid tumor cell lines and displayed moderate cytotoxicity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|