急性胰腺炎与氧化应激

氧化应激是在机体内活性氧生成和抗氧化物质失衡状态下,直接或间接通过信号转导通路引起细胞的损伤,是许多疾病的病因,同时又是许多疾病发生、发展的结果.研究表明,氧化应激在急性胰腺炎的发病中发挥重要作用,还与胰腺炎时胰腺外器官,如心、肝、肺、肾、消化道等的损伤有密切联系.氧化应激产生大量的活性氧和活性氮,引起炎症反应及微循环障碍,通过不同途径引起细胞坏死或凋亡,造成胰腺及其他脏器的功能障碍甚至衰竭.抗氧化剂可减少氧自由基的产生或直接清除机体产生的氧自由基,并增强机体的抗氧化能力,对急性胰腺炎具有较好的治疗作用.

Relationship between acute pancreatitis and oxidative stress

Under the imbalance between generation of reactive oxygen species and inadequate antioxi- dant defense systems,oxidative stress can cause cell damage either directly or indirectly through altering signaling pathways.It is the etiopatho- genisis and also the consequence of many dis- eases.Oxidative injury plays an important role not only in the pathogenesis of acute pancreati- tis (AP) but also in pancreatitis-induced dam- ages of other organs such as heart,liver,lung, kidney,alimentary canal and so on.Oxidative stress can produce a higher level of reactive oxy- gen species (ROS) and reactive nitrogen species (RNS),which induce inflammatory reaction and microcirculation disturbance,and cell necrosis or apoptosis,leading to pancreatic inflamma- tion and multiple organ dysfunction syndromes. The antioxidants can decrease the production of oxygen free radicals (or directly scavenge them), protect the antioxidant enzyme activity,rein- force the antioxidative capacity of bodies,and consequently play an obvious therapeutic effect on AP.