原发性肾病综合征患者肾小管间质病变的病理与临床特点

目的探讨原发性肾病综合征(PNS)患者中肾小管间质病变的临床意义.方法84例成人PNS按肾小管间质病变程度分为轻度、中度、重度三组,比较三组临床特征的异同.结果重度肾小管间质病变组高血压、贫血、血肌酐升高、肾小管功能受损发生率高,病程长、激素疗效差,与轻度病变组比较有显著性差异(P＜0.05);且重度病变组均伴有明显的肾小球硬化.结论伴有重度肾小管间质病变的PNS患者其临床、病理特点不同于轻度病变患者,肾小管间质病变是影响肾小球疾患患者预后的重要因素之一.

Cilinicopathological features of tubulointerstitial lesions in primary nephrotic syndrome

Objective: To explore the clinical significance of renal tubulointersitial lesions in patients with primary nephrotic syndrome. Methods:84 patients with primary nephrotic syndrome were divided into mild, moderate and severe groups according to degree of tubulointerstitial lesions, and clinicopathological data were analyzed retrospectively. Results: In severe group, the incidences of hypertension, anemia, and the levels of serum creatinine and urine 32 - MG were significantly higher than those in mild group ( P ＜ 0.05 ); the effect of prednisone treatment was poor and glomerular sclerosis was common in severe group. Conclusions: The elinicopathological features in PNS patients with severe tubulointerstitial lesions were different from those with mild tubulointerstitial lesions. Tubulointerstirial lesions are risk factors for prognosis of glomemlar diseases.