Comparison of New Sustained-Release Theophylline (E-0686) and Theo-Dur |
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| Authors: | Takuro Masaki MD Toshikazu Nagakura MD Hiroyuki Inui MD Yoshihiro Umesato MD Toshihiko Obata MD Yoji Likura MD |
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| Institution: | Department of Pediatrics, The Jikei University, School of Medicine;*Department of Allergy, National Children's Hospital |
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| Abstract: | New sustained-release theophylline (E-0686) was administered to asthmatic children to study changes in serum theophylline level and its reproducibility. Results are as follows: - 1) t-Max. of E-0686 was shorter than that of Theo-Dur, however, E-0686 could maintain a satisfactory serum theophylline level at 12 hours on a single dose.
- 2) A steady state was reached after three days on a multiple dose of E-0686. P-T difference of E-06 was 5.17 μg/ml, which could be sufficient for sustained-release theophylline.
- 3) Changes in serum theophylline level of E-0686 was highly reproducible.
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| Keywords: | Sustained-release theophylline E-0686 Theo-Dur Bioavailability |
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