胃巨大血管球瘤1例并文献复习

目的：探讨胃血管球瘤的临床、病理学特征以及诊断和鉴别诊断。方法：报道1例发生在胃部的血管球瘤，对其进行组织学、免疫组化检查并复习文献。结果：胃血管球瘤临床上多发于中年女性，好发于胃窦部，常见症状为上腹部疼痛；其形态学特点表现为肿瘤组织呈结节状，肿瘤细胞大小较一致，呈圆形或多边形，胞质透亮或嗜酸性，核圆形，瘤细胞排列成实性或围绕血管周围排列；免疫组化标记显示肿瘤细胞vimen-tin、SMA、aetin、calponin均为（＋），CK、CD117、Syn、S-100、EMA、desmin、CD99、CD34均（-）。结论：胃血管球瘤罕见，临床上缺乏特异性症状、主要表现为上腹部疼痛，生物学行为多为良性，具有特定的形态学特征和免疫表型，需要和其他肿瘤如上皮样胃间质瘤、类癌等进行鉴别。

A case report of gastric massive glomus tumor with literature review

Objective：To explore the clinicopathologic features, diagnosis and differential diagnosis of gastric glomus tumor. Methods： A case report with clinical, histological and immunohistoehemical studies and review of literature. Results： The tumor occurred more often in female and median age was 42 years, the tumor usually presented with epigastrie pain symptoms, most tumors were located in the antrum. Histologically, the tumor cells were uniform, round or polygonal, had clear or eosinophilie cytoplasm, nuclei were round, the tumor cells had a solid pattern or ar- ranged around blood vessels. Immunohistoehemically, all tumors were positive for vimentin, SMA, aetin and ealponin, while other markers including CK, CD117, S100, desmin, Syn, CD99 and CD34 were negative. Conclusion ： Gastric glomus tumor is a rare benign tumor and usually occurs in female, with distinct morphological and immunohistoehemieal features and needs to be differentiated from other tumors such as epithelioid stromal tumors, myoperieytoma and eareinoid tumor in the gastrointestinal tract.