Antioxidant effect of vitamin E and selenium on hepatotoxicity induced by dimethoate in female adult rats |
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Authors: | Ben Amara Ibtissem Soudani Nejla Troudi Afef Bouaziz Hanen Boudawara Tahia Zeghal Najiba |
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Institution: | a Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Science, University of Sfax, BP1171, 3000 Sfax, Tunisia b Anatomopathology Laboratory, University of Sfax, CHU Habib Bourguiba, 3029 Sfax, Tunisia |
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Abstract: | Acute exposure to pesticides can cause hepatotoxicity. Our study pertains to the potential ability of selenium and/or vitamin E, used as nutritional supplements, to alleviate oxidative stress induced by dimethoate. Female Wistar rats were randomly divided into seven groups of six each: group I served as controls; group II received in their drinking water dimethoate (2 g L−1); group III received both dimethoate and selenium (0.5 mg/kg of diet); group IV was treated with dimethoate and vitamin E (100 mg/kg of diet); group V received dimethoate+selenium+vitamin E and groups VI and VII received either selenium or vitamin E. The exposure of rats to dimethoate for 30 days promoted oxidative stress with an increase in malondialdehyde and a decrease in glutathione and non-protein thiol levels. A decrease in glutathione peroxidase, superoxide dismutase and catalase activities was also observed. While, plasma transaminases, lactate dehydrogenase activities and bilirubin levels increased. Co-administration of selenium and/or vitamin E through diet improved the biochemical parameters cited above. Liver histological studies confirmed biochemical parameters and the beneficial roles of selenium and vitamin E. |
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Keywords: | Dimethoate Selenium Vitamin E Hepatotoxicity Antioxidant activities Rats Histopathological studies |
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