| HPLC法测定复方阿司匹林酊中阿司匹林的含量 |
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| 引用本文： | 张应辉,赵彬琳,吴雪,甘智瑜. HPLC法测定复方阿司匹林酊中阿司匹林的含量[J]. 解放军药学学报, 2012, 28(6): 527-528,560 |
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| 作者姓名： | 张应辉 赵彬琳 吴雪 甘智瑜 |
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| 作者单位： | 解放军181医院药剂科,广西桂林,541002 |
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| 摘 要： | 目的建立HPLC法测定复方阿司匹林酊中阿司匹林的含量。方法色谱条件：色谱柱为C8柱（5μm,150mm×4.6 mm）;流动相：乙腈-水-冰醋酸（20∶75∶1）;进样量为20μl;流速为1 ml.min-1;检测波长为277 nm;柱温为28℃。结果阿司匹林在20.16～141.12μg.ml-1范围内呈良好的线性关系（r=0.9999）;平均回收率为99.88%,RSD为1.09%（n=6）。结论本方法专属性强,重复性好,精密度高,可用于复方阿司匹林酊的质量控制。
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| 关 键 词： | HPLC 阿司匹林酊 含量测定 |
Determination of Aspirin Content in Compound Aspirin Tincture by HPLC |
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| ZHANG Ying-hui , ZHAO Bin-lin , WU Xue , GAN Zhi-yu. Determination of Aspirin Content in Compound Aspirin Tincture by HPLC[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2012, 28(6): 527-528,560 |
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| Authors: | ZHANG Ying-hui ZHAO Bin-lin WU Xue GAN Zhi-yu |
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| Affiliation: | Hospital 181 of CPLA,Guilin 541002,China |
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| Abstract: | Objective To establish an HPLC method for determination of the content of aspirin in compound aspirin tincture. Methods The chromatographic column（ Cs, 150 mm x 4.6 mm,5 μm） was adopted with acetonitrile-water-glacial acetic acid （20： 75：1 ） as the mobile phase at a the flow rate of 1 ml -min-1. The detection wavelength was set at 277 nm and column temperature at 28 ℃. Results The linear range of aspirin was 20.16-141.12 μg .m1-1 ,with a good linear correlation（ r =0.9999）. The average recovery of aspirin was 99.88% with RSD at 1.09% （ n = 6）. Conclusion This method is highly specific and accurate, which can be used for quality control of compound aspirin tincture. |
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| Keywords: | HPLC compound aspirin tincture assay |
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