| 鱼金清解口服液质量标准研究 |
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| 引用本文： | 肖引,兰怡,陈江,李亚男,王夕静. 鱼金清解口服液质量标准研究[J]. 解放军药学学报, 2012, 28(6): 523-526 |
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| 作者姓名： | 肖引 兰怡 陈江 李亚男 王夕静 |
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| 作者单位： | 1. 武警陕西总队医院,陕西西安,710054
2. 西安新通药物研究有限公司,陕西西安,710077 |
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| 摘 要： | 目的建立鱼金清解口服液的质量控制标准。方法采用TLC法对制剂中槲皮苷进行定性鉴别;采用GC法对制剂中芳樟醇进行定性鉴别;采用HPLC法对制剂中绿原酸进行定量测定;采用GC法对制剂中甲基正壬酮进行定量测定。结果 TLC法能检出鱼腥草中的槲皮苷;GC法能检出金银花中的芳樟醇;绿原酸在0.104～2.608μg范围内呈良好的线性关系,r=1.0000,平均回收率为100.3%,RSD=1.37%;甲基正壬酮在1.7932～71.728μg.ml-1范围内呈良好的线性关系,r=1.0000,平均回收率为102.4%,RSD为1.7%。结论本课题所建立的质量标准方法稳定、准确、重复性好,可用于该制剂的质量控制。
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| 关 键 词： | 绿原酸 甲基正壬酮 |
Quality Standard for Yujin Qingjie Oral Liquid |
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| XIAO Yin , LAN Yi , CHEN Jiang , LI Ya-nan , WANG Xi-jing. Quality Standard for Yujin Qingjie Oral Liquid[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2012, 28(6): 523-526 |
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| Authors: | XIAO Yin LAN Yi CHEN Jiang LI Ya-nan WANG Xi-jing |
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| Affiliation: | ② ①Shaanxi Provincial Corps Hospital of Chinese People′s Armed Police Forces,Xi′an 710054,China; ②Xi′an Xintong Pharmaceutical Research Co.,Ltd,Xi′an 710077,China |
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| Abstract: | Objective To establish a quality standard for Yujin Qingjie Oral Liquid. Methods Quercitrin was identified by TLC and linalool by GC. Chlorogenie acid was determined by HPLC and methyl-n-nonylketone by GC. Results Quercitrin could be detected by TLC and linalool by GC. Chlorogenic acid showed a good linear relationship within the range of 0. 104-2.608 μg, r = 1. 0000. The average recovery was 100.3%, and RSD was 1.37%. The line- arity of methyl-n-nonylketone was 1. 7932-71. 728 μg -m1-1, r = 1. 0000. The average recovery was 102.4%, and RSD was 1.7%. Conclusion The established method is stable, accurate and reproductive. |
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| Keywords: | chlorogenic acid methyl-n-nonylketone |
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