绝经期前后诸证与血液流变学

中医认为，绝经期前后诸证的产生与脏腑功能衰退关系甚大，故临床上多从虚证治疗。为了探讨本病与血液流变学的改变是否有相关的因素存在，作者对４０例患有绝经期前后诸证的妇女，按中医辩证分为脾肾阳虚及肝肾阴虚二组，用ＸＮ－５型带微电脑毛细血管粘度计，对其分别作了血液流变学的５项测定，以２０例处于更年时期无明显临床表现的患者作对照组，结果表明，脾肾阳虚组患者的全血粘度、红细胞聚集指教及红细胞压积值均明显低于肝肾阴虚组，这改变为临床鉴别两型的病变程度提供了微观辩证的客观指标，有助于今后进行较为准确的临床辩证和用药。

EFFECTS OF RANITIDINE ON BRONCHIAL RESPONSIVENESS IN ASTHMATIC SUBJECTS

In this investigation,we selected 13 asthmatic patients coexisted gastroesophageal reflux disease(GERD)and 14 asthmatic subjects without GERD,patients with or without GERD were documented with barium esophagram and esophageal endoscopy.All patients were administered with ranitidine 150mg,twice daily for eight weeks.We found that the asthmatic symptoms were significantly exacerbated and the FVC%Pred,FEV 1,FEV 1/FVC, 50 , 25 ,histamine PC 20-FEV 1 were significantly decreased after ranitidine treatment in the group of patients without GERD.The refluent and asthmatic symptoms were significantly relieved and the VC,VC%Pred,FVC,FVC%Pred,FEV 1,FEV 1/FVC, 50 , 25 ,histamine PC 20-FEV 1 were significantly increased after ranitidine antireflux treatment in the group of asthmatics with GERD.These results suggest that the effects of ranitidine on bronchial responsiveness in asthmatic subjects are related to patients with or without GERD.