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氯乙烯致大鼠肝细胞DNA损伤的离体实验研究
引用本文:王民生. 氯乙烯致大鼠肝细胞DNA损伤的离体实验研究[J]. 工业卫生与职业病, 1998, 24(4): 219-222
作者姓名:王民生
作者单位:江苏省职业病防治研究所!南京市,210028,江苏省职业病防治研究所!南京市,210028,江苏省职业病防治研究所!南京市,210028,江苏省职业病防治研究所!南京市,210028,联邦德国癌症研究中心,联邦德国癌症研究中心
摘    要:应用单细胞微量凝胶电泳测试技术检测氯乙燃对哺乳动物肝肘细胞DNA损伤情况。结果发现:氯乙烯可致肝实质性细胞DNA损伤,呈剂量-效应关系,对肝非实质性细胞只有在与肝实质性细胞混合培养时才出现一定程度的DNA损伤。

关 键 词:氯乙烯 DNA损伤 微量凝胶电泳 肝细胞

DNA DAMAGE IN RAT LIVER CELLS INDUCED BY VINYL CHLORIDE IN VITRO
Wang Minsheng, et al. DNA DAMAGE IN RAT LIVER CELLS INDUCED BY VINYL CHLORIDE IN VITRO[J]. Industrial Health and Occupational Diseases, 1998, 24(4): 219-222
Authors:Wang Minsheng   et al
Abstract:In order to investigate cell specific genotoxicity of vinyl chloride, rat liver parenchymal cellsand nonparenchymal cells were studied in vitro by microgel single cell electrophoresis assay (cometassay). Results showed that vinyl chloride could distinctively induce dose-dependent increase ofDNA damage in parenchymal liver cells,while in nonparenchymal liver cells only weak effects werefound after coincubated with hepatocytes. Nonparenchymal cells seemed not so sensitive togenotoxicity of vinyl chloride as parenchymal cells.
Keywords:Vinyl chloride  Comet assay  DNA damage  Liver cell
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