胃痛消痞方治疗肝郁型功能性消化不良大鼠的疗效及作用机理研究

目的：观察胃痛消痞方对功能性消化不良肝郁型大鼠胃内残留量,血浆胃动素（MTL）、血清一氧化氮（NO）含量的影响。方法：用夹尾激怒法制作肝郁型功能性消化不良大鼠模型,随机分为模型组、空白组、中药低、中、高剂量组,吗丁啉组,分别用生理盐水、胃痛消痞方高、中、低剂量组、吗叮啉,每日2次灌胃,持续14天,测定各组大鼠胃内残留量及MTL、NO的含量。结果：胃痛消痞方能减少胃内残留量（P〈0.05）,中剂量组疗效优于高、低剂量组（P〈0.05）。胃痛消痞方高、中剂量组提高MTL的水平,各剂量组均降低NO的水平（P〈0.05）。结论：胃痛消痞方能提高MTL的水平及降低NO的分泌,减少胃残留量。

The Study of the Efficacy and Mechanism of Weitongxiaopi Decoction on the Functional Dyspepsia Rats models with Liver qi depression-type

Objective：To observe of influence of Weitongxiaopi Decoction on gastric residual volume,plasma motilin（MTL）and serum nitric oxide（NO） in functional dyspepsia Rats models with Liver qi depression-type.Methods：The Functional Dyspepsia Rats models with Liver qi depression-type were induced by stimulating rats on tails with forceps clip.then the rats were randomly divided into： Model group,blank control group,Weitongxiaopi Decoction high,medium,low-dose group,and Domperidone group;normal saline、different concentrations of Weitongxiaopi Decoction and Domperidone were given to six groups,fed twice a day by gastrogavage,sustained for 14days;observe of Rats＇ gastric residual volume,MTL and NO content.Results：Weitongxiaopi Decoction can only significantly reduced gastric residual volume（P0.05）,middle dose group more effective than high-and low-dose group（P0.05）.Weitongxiaopi Decoction of high,medium-dose group can improve the level of MTL,each dose group were lower NO levels（P0.05）.Conclusion：Weitongxiaopi Decoction can improve the level of MTL and reduced secretion of NO,thus reduced gastric residual volume.