| 博莱霉素致大鼠肺纤维化模型肺组织不同时间点的动态演变 |
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| 引用本文： | 吕晓东,庞立健. 博莱霉素致大鼠肺纤维化模型肺组织不同时间点的动态演变[J]. 中医药学刊, 2010, 0(3): 508-511 |
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| 作者姓名： | 吕晓东 庞立健 |
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| 作者单位： | 辽宁中医药大学附属医院,辽宁沈阳110032 |
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| 基金项目： | 辽宁省自然基金资助项目（20052067） |
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| 摘 要： | 目的：观察博莱霉素（BLM）致大鼠肺纤维化模型肺组织不同时间点动态演变过程。方法：采用博莱霉素气管内注入致Wistar大鼠肺纤维化模型,用HE、MASSON染色观察肺组织病理形态不同时间点的演变。结果：随着时间的延长,肺纤维化大鼠肺组织肺泡炎、纤维化、胶原沉积不断加重。结论：博莱霉素致大鼠肺纤维化模型肺组织动态演变具有时相型。
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| 关 键 词： | 肺纤维化 动态演变 BLM |
Bleomycin Induced Rat Model of Pulmonary Fibrosis Lung Tissue at Different Time Points Dynamic Evolution Process |
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| LU Xiao-dong,PANG Li-jian. Bleomycin Induced Rat Model of Pulmonary Fibrosis Lung Tissue at Different Time Points Dynamic Evolution Process[J]. Study Journal of Traditional Chinese Medicine, 2010, 0(3): 508-511 |
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| Authors: | LU Xiao-dong PANG Li-jian |
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| Affiliation: | (Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China) |
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| Abstract: | Objective：Observation of bleomycin （BLM） induced rat model of pulmonary fibrosis lung tissue at different time points dynamic evolution process.Methods：Used intratracheal instillation of bleomycin-induced pulmonary fibrosis Wistar rat model,Observed the evolution of different time points of lung by HE,MASSON.Results：With the extension of time,alveolitis,fibrosis,and collagen deposition increasing.Conclusion：Bleomycin （BLM） induced rat model of pulmonary fibrosis lung tissue with dynamic phase of evolution. |
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| Keywords: | PF Dynamic evolution BLM |
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