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ATP敏感性钾通道与心肌保护的研究新进展
引用本文:张娜,章怡祎,韩向辉,蔡珏锋,刘萍. ATP敏感性钾通道与心肌保护的研究新进展[J]. 中医药学刊, 2010, 0(5): 998-1000
作者姓名:张娜  章怡祎  韩向辉  蔡珏锋  刘萍
作者单位:上海中医药大学龙华医院,上海200032
基金项目:国家教育部科学技术研究重点项目(208042); 上海市教委重点项目(07ZZ56)
摘    要:缺血预处理(IP)和缺血后处理(POC)对心肌缺血/再灌注损伤有一定的保护作用,ATP敏感性钾通道是IP、POC的重要环节。因而KATP通道在调节心肌细胞缺血、缺氧的病理生理反应中起重要作用。对KATP通道结构、功能调控,在IP、POC中的心肌保护作用以及中药在该领域的研究进展作一综述。

关 键 词:ATP敏感性钾通道  心肌保护  研究进展

Recent Advance in Research on ATP-sensitive Potassium Channels and Myocardial Preservation
ZHANG Na,ZHANG Yi-yi,HAN Xiang-hui,CAI Jue-feng,LIU Ping. Recent Advance in Research on ATP-sensitive Potassium Channels and Myocardial Preservation[J]. Study Journal of Traditional Chinese Medicine, 2010, 0(5): 998-1000
Authors:ZHANG Na  ZHANG Yi-yi  HAN Xiang-hui  CAI Jue-feng  LIU Ping
Affiliation:(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
Abstract:Ischemic preconditioning (IP) and ischemic postconditioning (POC) have protective effects on myocardial ischemia/reperfusion injury,while ATP-sensitive potassium channels (KATP channels) play a key role in IP and POC of the heart.Activation of this potassium channel contributes to the regulation of myocardial cell injury during hypoxia and ischemia.Below,this paper will review and discuss current studies on correlating structure,function and myocardial protection of KATP channels.
Keywords:ATP-sensitive potassium channels  myocardial protection  advance in research
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