| 白首乌体外抑制肿瘤细胞成分研究 |
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| 引用本文： | 徐佳丽,厉国强,黄维洁,张如松.白首乌体外抑制肿瘤细胞成分研究[J].中医药学刊,2010(2):416-418. |
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| 作者姓名： | 徐佳丽 厉国强 黄维洁 张如松 |
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| 作者单位： | 浙江中医药大学,浙江杭州310053 |
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| 摘 要： | 目的：首乌块根中分离出C21甾体苷单体,并研究其抗肿瘤活性。方法：运用柱色谱和HPLC分离纯化,通过IR,1HNMR,13C NMR,ESI鉴定出其化学结构。结果：从白首乌中分离出3种C21甾体苷,它们分别是告达庭3-O-β-D-磁麻吡喃糖基-（1→4）-β-D—磁麻吡喃糖苷、告达庭3-O-β-D-夹竹桃吡喃糖基-（1→4）-β-D—磁麻吡喃糖基-（1→4）-β-D—磁麻吡喃糖苷、告达庭3-O-β-D-磁麻吡喃糖基-（1→4）-β-D—夹竹桃吡喃糖基-（1→4）-β-D—磁麻吡喃糖基-（1→4）-β-D—磁麻吡喃糖苷,分离得到的这3种C21甾体苷均具有抗肿瘤作用。结论：从白首乌中分离得到的3种C21甾体苷对肿瘤细胞的抑制作用具有选择性。
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| 关 键 词： | 白首乌 甾体苷单体 肿瘤作用 MTT法 |
Studies on the Chemistry and Antieoplastic Activities in the Root of Cynanchum Auriculatum |
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| XU Jia-li,LI Guo-qiang,HUANG Wei-jie,ZHANG Ru-song.Studies on the Chemistry and Antieoplastic Activities in the Root of Cynanchum Auriculatum[J].Study Journal of Traditional Chinese Medicine,2010(2):416-418. |
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| Authors: | XU Jia-li LI Guo-qiang HUANG Wei-jie ZHANG Ru-song |
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| Institution: | (College of Pharmacy,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China) |
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| Abstract: | Objective：To isolate monomers of C21 steroid glycosides from the root of Cynanchum Auriculatum and study their cytotoxic activities.Methods：By using the and HPLC,and through the IR,1H NMR,13C NMR,ESIidentify their chemical structures.Results：Isolate three kinds of C21 Steroidal Glycosides from Cynanchum Auriculatum,they are caudatin 3-β-D-cymaropyranosyl-（1→4）-β-D-cymaropyranoside,caudatin-3-β-D-cymaropyranosyl-（1→4）-β-D-cymaropyranosyl-（1→4）-a-D-oleandropyranoside and caudatin 3-β-D-cymaropyranosyl-（1→4）-β-D-cymaropyranosyl-（1→4）-β-D-oleandropyranosyl-（1→4）-β-D-cymaropyranoside,which have inhibitory effect on cancer cell.Conclusion：The inhibitory effect on cancer cell of this three kinds of C21 Steroidal Aglycosides have selectivity. |
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| Keywords: | Cynanchum Auriculatum C21 steroid glycosides monomers inhibitory effect on cancer cell MTT method |
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