消痔灵双层四步注射治疗完全性直肠脱垂临床疗效评价

目的：客观评价消痔灵双层四步注射治疗完全性直肠脱垂的临床疗效与安全性。方法：将36例患者随机分为A、B两组,A组20例为高浓度组;B组16例为低浓度组,采取双层四步注射疗法。以直肠脱垂长度、排粪造影结果作为疗效性指标,患者一般情况、全血细胞分析、肝功能检查作为安全性指标。并进行3个月1次的随访。结果：A组临床控制19例,有效1例;B组临床控制16例。两组近期疗效未见显著差异,均未见严重肝肾功能损害,经3～36个月随访,复发7例。复发病例中有4例经再次注射而达到临床控制,1例行开腹作肠管切除术,1例行开腹直肠悬吊固定术,1例行经吻合器的直肠黏膜环形切除术（PPH手术）达到临床控制。结论：该疗法具有操作简便、安全有效、痛苦较小、费用低廉、且可重复使用的优点,可作为完全性直肠脱垂的首选治疗方法。

Evaluation of Curative Effect of Xiaozhiling Injection Double-layer Four-step Inject Therqpy of Full Thickness Rectal Prolapse-attached Report

Objective：To evaluate the clinical curative effect and security of therapy of xiaozhiling injection of complete rectal prolapse.Mrthods：36 patients that were randomly divided into group A and B were taken double-layer four-step inject therapy.A was group of high concentration with 20 patients,and B was group of low concentration with 16 patients.The length of rectal prolapse and radiography of defecation were the indicators of curative effect,and the indicators of security were the general conditions of patients,the blood cell analysis and the function of liver and kidney.Follow-ups were takesn every three months.Results：In group A,19 patients were clinical controlled and 1 case was effective.In group B,16 patients were clinical controlled.There was no statistically significant effect between the two groups （P〉0.05）,Liver and kidney function had no serious damage.After 3-36months＇ follow-up,7 cases recurred.Of the 7 patients,4 were clinical controlled after the second time injection,1 was taken intestine resection,1 was taken sling fixation of rectum,1 was taken PPH.Conclusion：The therapy is painless,effective,simple,low-cost and repeatable.Which is appropriate for being generalized in the grass roots hospitals as preferred method.