| 慢性阻塞性肺疾病急性发作期痰白介素－8及白介素－16的检测及意义 |
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| 引用本文： | 吴聪,柳广南,钟小宁.慢性阻塞性肺疾病急性发作期痰白介素－8及白介素－16的检测及意义[J].广西医学,1999,21(3):380-383. |
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| 作者姓名： | 吴聪 柳广南 钟小宁 |
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| 作者单位： | 广西医科大学第一附院呼吸内科 |
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| 摘 要： | 目的：探讨白细胞介素－８（ＩＬ－８）及白细胞介素－１６（ＩＬ－１６）在慢性阻塞性肺疾病（ＣＯＰＤ）气道炎症中的作用。方法：采用酶联免疫吸附法（ＥＬＩＳＡ）检测收集到的ＣＯＰＤ患者急性发作期及正常人的痰ＩＬ－８及ＩＬ－１６水平。结果：ＣＯＰＤ患者急性发作期痰ＩＬ－８及ＩＬ－１６水平明显高于正常对照组的水平（Ｐ〈０．０５），ＣＯＰＤ患者痰液ＩＬ－８与ＦＥＶ１呈负相关（ｒ＝－０．６７，Ｐ〈０．０１），其
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| 关 键 词： | 阻塞性肺疾病 COPD 急性发作期 痰 IL－8 IL－16 |
Detection and significance of interleukin-8 and interleukin-16 in induced sputum from acute chronic obstructive pulmonary disease |
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| Wu Cong,Liu Guangnan,Zhong Xiaoning,et al.Detection and significance of interleukin-8 and interleukin-16 in induced sputum from acute chronic obstructive pulmonary disease[J].Guangxi Medical Journal,1999,21(3):380-383. |
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| Authors: | Wu Cong Liu Guangnan Zhong Xiaoning |
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| Institution: | Nanning 530021 |
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| Abstract: | Objective:To explore the role of IL-8 and IL-16 in the airway inflammation of chronic obstructive pulmonary disease(COPD)Method:IL-8 and IL-16 of induced sputum in some patients with acute COPD and health controls were detected by ELISA methodResult:IL-8 and IL-16 of induced sputum in patients with acute COPD were much higher than those in health controlsIn addition,there was more inverse correlation between IL-8 of induced sputum and FEV1 in patients with COPD(r=-067,P<001),there was also the same correlation between IL-16 of induced sputum and FEV1(r=045,P<005)Conclusion;IL-8 and IL-16 might play important roles in the airway inflammation of COPD,and IL-8 appeared more important in them |
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| Keywords: | COPD IL-8 IL-16 Airway inflammation |
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