| 环氧合酶-2在骨肉瘤中的表达及与血管内皮生长因子相关性的研究 |
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| 引用本文： | 姜宇,杨述华,李进,刘勇,许伟华. 环氧合酶-2在骨肉瘤中的表达及与血管内皮生长因子相关性的研究[J]. 中国矫形外科杂志, 2004, 12(11): 845-847 |
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| 作者姓名： | 姜宇 杨述华 李进 刘勇 许伟华 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院骨科,武汉430022 |
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| 摘 要： | 目的 :探讨环氧合酶 2 (COX 2 )在骨肉瘤中的表达及其与肿瘤血管内皮生长因子 (VEGF)的相关性。方法 :应用免疫组织化学染色的方法研究人骨肉瘤组织中COX 2和VEGF的表达。结果 :COX 2在骨肉瘤中表达阳性率为 67 7% ,而VEGF表达阳性率为 5 8 1%。COX 2表达与VEGF表达显著相关 (γS=0 5 676,P <0 0 5 )。结论 :骨肉瘤组织中存在COX 2的高表达 ,COX 2与骨肉瘤的新生血管生成密切相关 ,其高表达可能促进了肿瘤新生血管生成
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| 关 键 词： | 环氧合酶-2 骨肉瘤 血管内皮生长因子 |
| 文章编号： | 1005-8478(2004)11-0845-03 |
| 修稿时间： | 2003-12-22 |
Expression of cyclooxypenase 2 and the correlation between cyclooxypenase 2 and vascular endothelial growth factor in osteosarcoma |
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| JIANG Yu,YANG Shu-hua,LI Jin,et al.. Expression of cyclooxypenase 2 and the correlation between cyclooxypenase 2 and vascular endothelial growth factor in osteosarcoma[J]. The Orthopedic Journal of China, 2004, 12(11): 845-847 |
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| Authors: | JIANG Yu YANG Shu-hua LI Jin et al. |
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| Affiliation: | JIANG Yu,YANG Shu-hua,LI Jin,et al.Department of Orthopedics,Union Hospital of Tongji Medical College of Huazhong Science and Technology University,Wuhan 430022 |
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| Abstract: | Objective:To investigate the expression of cyclooxypenase 2 (COX-2) and the effect of cyclooxypenase 2 (COX-2) on vascular endothelial growth factor (VEGF) in osteosarcoma.Method:The expression of COX-2,VEGF in human osteosarcoma tissue was analyzed with immunohistochemistry.Result:The positive rate of COX-2 expression was 67.7% and the positive rate of VEGF expression was 58.1% in osteosarcoma,and there was a positive correlation between expression of COX-2 and VEGF.Conclution:COX-2 overexpression is found in human osteosarcoma.Expression of COX-2 may contribute to angiogenesis in osteosarcoma,this action is probably related to the production of angiogenic factors such as VEGF modulated by COX-2. |
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| Keywords: | Osteosarcoma Cyclooxypenase 2 Vascular endothelial growth factor |
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