| 2型糖尿病患者皮质醇水平及下丘脑-垂体-肾上腺轴活性 |
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| 引用本文： | 王丽华,刘伟,李圣贤,黄融,成琦,邬亦华. 2型糖尿病患者皮质醇水平及下丘脑-垂体-肾上腺轴活性[J]. 中华内分泌代谢杂志, 2008, 24(5) |
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| 作者姓名： | 王丽华 刘伟 李圣贤 黄融 成琦 邬亦华 |
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| 作者单位： | 上海交通大学医学院附属仁济医院内分泌科,200127 |
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| 摘 要： | 本研究评价2型糖尿病患者皮质醇水平及调节.测定血、尿皮质醇,行地塞米松抑制试验及醋酸可的松试验.糖尿病患者尿皮质醇水平高于正常对照组,其肝脏11β-羟类同醇脱氧酶活性较正常人群明显下降.提示2型糖尿病患者有较高的基础皮质醇水平,其原因可能为肝脏对皮质醇的降解代谢受损.
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| 关 键 词： | 糖尿病,2型 皮质醇 下丘脑-垂体-肾上腺轴 |
Investigation of the plasma cortisol and the function of hypothalamic-pituitary-adrenal axis in type 2 diabetic patients |
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| WANG Li-hua,LIU Wei,LI Sheng-xian,HUANG Rong,CHENG Qi,WU Yi-hua. Investigation of the plasma cortisol and the function of hypothalamic-pituitary-adrenal axis in type 2 diabetic patients[J]. Chinese Journal of Endocrinology and Metabolism, 2008, 24(5) |
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| Authors: | WANG Li-hua LIU Wei LI Sheng-xian HUANG Rong CHENG Qi WU Yi-hua |
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| Abstract: | The plasma level and the regulation of cortisol in type 2 diabetic patients were invesligated.Plasma and urinary cortisol levels were measured, and dexamethasonc suppression test and oral cortisone test in vivo were performed. Compared with controls, diabetic patients had higher urinary cortisol level. The activity of hepatic 11 β-hydroxy-steroid dehydrogenase-1 (11β-HSD1) in type 2 diabetic patients was decreased, suggesting that the elevated basal cortisol in type 2 diabetic patiens may due to impaired hepatic degradation of cortisol. |
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| Keywords: | Diabetes meUitua,type 2 Cortisol Hypothalamic-pituitary-adrenal axis |
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