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Competitive inhibition between folic acid and methotrexate for transport carrier in the rat small intestine |
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| Authors: | V S Chungi D W Bourne L W Dittert |
| Abstract: | Folic acid absorption from the lumen of the rat small intestine in situ obeyed Michaelis--Menten kinetics. The values of Vmax and Km for absorption were 4.63 x 10(-7) M/min and 1.21 x 10(-6) M, respectively. Folic acid and methotrexate were mutual competitive inhibitors of absorption. Their Ki values were 1.28 x 10(-6) and 1.9 x 10(-5) M, respectively. |
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