HPV16/18感染与卵巢癌的关系 |
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引用本文: | 柏青杨,徐凤琳,陈小艳.HPV16/18感染与卵巢癌的关系[J].齐齐哈尔医学院学报,2009,30(7):769-770. |
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作者姓名: | 柏青杨 徐凤琳 陈小艳 |
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作者单位: | 齐齐哈尔医学院病理教研室,161006 |
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摘 要: | 目的探讨高危型人乳头状瘤病毒感染与卵巢癌发生的关系。方法采用原位杂交法检测卵巢上皮性良性肿瘤32例、交界性肿瘤25例、卵巢癌45例中HPV16/18病毒,用正常卵巢组织作对照。结果卵巢癌中HPV16/18的感染与正常卵巢组织、上皮性良性肿瘤比较均有显著性差异(P〈0.001),与交界性肿瘤比较无差异;低分化卵巢癌中HPV16/18的感染率高(P〈0.05),与患者组织学类型及临床分期等无关。结论高危型HPV的感染可能与卵巢癌的发生有关。
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关 键 词: | 卵巢癌 高危型人乳头瘤病毒 原位杂交 |
Correlation of High-Risk Human Papillomavirus with Ovarian Carcinomas |
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Institution: | BAI Qing - yang ,et al. (Pathology Department,Qiqihar Medical University, Qiqihar, Heilongjiang 161006 ,China) |
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Abstract: | Objective To explore the relation between the High-risk human papillomavirus (HPV) and ovarian carcinomas. Methods In situ, Hybridization Technique was used to examine HPV16/18 DNA in 32 cases of benign Ovarian epithelial tumors,25 cases of borderline tumors,45 cases of Ovarian carcinoma and immunobistochemistry was used to examine the expression of VEGF and ki- 67 protein,which compared to usual ovarian tissues. Results The positive rate of HPV16/18 was significantly different between ovarian carcinoma and normal epithelial ovarian tissues or benign epithelial ovarian tumors (P 〈 0. 001), but no significant difference between ovarian carcinomas and borderline tumors; The percentage of positive expression of HPV16/18 was evidently higher in the poorly differentiated ovarian carcinomas than that of the well differentiated group (P 〈 0.05), and was not associated with tumor types or clinical stages. Conclusions The infection of High-risk HPV may be.related to the development of ovarian carcinoma. |
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Keywords: | Ovarian carcinomas High-risk human papilloma virus(HPV) In situ hybridization |
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