男性STD病人治疗后泌尿道念珠菌感染情况及药敏分析

目的了解男性STD病人治疗后泌尿道念珠菌的感染情况及对常用抗真菌药物的敏感状况,为临床治疗提供参考。方法取治疗后的STD患者前列腺液和无菌尿液,进行念珠菌培养、鉴定和药敏试验;同时设健康对照。结果104例患者阳性标本17例,阳性率16. 4%,分离到念珠菌18株,其中白念珠菌8株,光滑念珠菌2株,热带念珠菌1株,其他7株。药敏结果显示两性霉素B敏感性最高(100% ),酮康唑和5-氟胞嘧啶敏感性最低(66. 7% ); 313例健康男性分离到念珠菌24株,阳性标本23例,阳性率7. 3%,其中白念珠菌2株,光滑念珠菌6株,其他16株。药敏结果示两性霉素B敏感性最高(100% ),氟康唑敏感性最低(75. 0% )。结论　男性STD病人治疗后泌尿生殖道念珠菌检出率明显高于健康男性,检出菌种仍以白念珠菌为主;念珠菌对两性霉素B最敏感,对唑类药物有耐药。STD病人和健康人群泌尿道分离的念珠菌对常用抗真菌药物的耐药率差异无显著性。

Male Patients after Treatment Infected State and Analysis on Antifungal Susceptibility of Candida in Urinary Tract from Sexually Transmitted Diseases

Objective To realize the male patients after treatment infected state and antifungal susceptibility of Candida in urinary tract from sexually transmitted diseases,and provide the reference material for the clinical treatment.Methods To collect the prostatic and aseptic urinary liquid from STD male patients after treatment,and cultivate these specimens,identify and determine the antifungal susceptibility and set the control from those of healthy men.Results 18 strains Candida were isolated from 104 STD male patients,and there were 17 positive specimens in all of specimens,therefore,the positive rate was 16.4% among patients.Of these strains,there are 8 Candida albicans,2 Candida glabrata,1 Candida tropical,and 7 others strains,respectively.It is revealed from the result of drug susceptibility that AMB was the most susceptible drug(100%) and 5-FC and KETO was the least susceptible drug(66.7%).Besides,24 strains Candida were isolated from healthy male college students,and there were 23 positive specimens in all of specimens,therefore,the positive rate was 7.3% among healthy group.Of these strains,there were 2 Candida albicans,6 Candida glabrata,and 16 others strains,respectively.It was revealed from the result of drug susceptibility that AMB was the most susceptible drug(100%) and FCZ was the least susceptible drug(75.0%).Conclusions The infective rate of Candida in urinary tract from STD patients after treatment is significantly higher than that of healthy men,the commonly antifungal susceptibility to Candida is different,the most susceptible drug for Candida from STD patients is AMB,however,it exists resistance for these stains to azoles drug.There is no difference in significance for drug-resistant rate of Candida between STD diseases and healthy people group.