| 来源于天然产物的抗肿瘤先导结构研究进展 |
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| 引用本文： | 武善超,盛春泉,张万年.来源于天然产物的抗肿瘤先导结构研究进展[J].药学实践杂志,2014,32(5):337-341,371. |
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| 作者姓名： | 武善超 盛春泉 张万年 |
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| 作者单位： | 第二军医大学药学院, 上海 200433,第二军医大学药学院, 上海 200433,第二军医大学药学院, 上海 200433 |
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| 基金项目： | 国家自然科学基金重点项目(30930107). |
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| 摘 要： | 肿瘤严重威胁人类生命健康,因此发现新结构类型、新作用机制、更有效的抗肿瘤药成为当务之急。天然产物在抗肿瘤药物发现过程中有着重要的作用和意义。综述几种具有抗肿瘤活性的天然产物,重点阐述其作用机制、抗肿瘤活性及构效关系的研究进展。
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| 关 键 词： | 天然产物 抗肿瘤先导结构 抗肿瘤活性 作用机制 构效关系 |
| 收稿时间： | 2013/3/11 0:00:00 |
| 修稿时间： | 2013/6/25 0:00:00 |
Advance in anti-cancer lead-compounds derived from natural products |
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| WU Shanchao,SHENG Chunquan and ZHANG Wannian.Advance in anti-cancer lead-compounds derived from natural products[J].The Journal of Pharmaceutical Practice,2014,32(5):337-341,371. |
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| Authors: | WU Shanchao SHENG Chunquan and ZHANG Wannian |
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| Institution: | School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China and School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Cancer is a serious threat to human life and health. Therefore, there is an emergent need to develop novel anti-cancer agents with new structural type, new mechanism of action and higher efficacy. Natural products had played a key role in the discovery of anticancer agents. The anti-cancer activity, mechanism of action, structure and activity relationship of several lead-compounds which were derived from natural products were summarized in this review. |
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| Keywords: | natural products anti-cancer lead-compounds anti-cancer activity mechanism of action structure and activity relationship |
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