172例人血清蛋白临床应用合理性调查与分析

目的 评价人血清蛋白的临床应用情况,并为临床合理用药提供实证。方法 利用美康合理用药临床药学工作站,从该院2010年应用人血清蛋白的住院患者中,随机抽取172例,对所选病例进行回顾性分析,获取有关临床应用信息,包括患者的年龄、性别、科室、诊断、疗程、用药原因、用药前白蛋白浓度等指标,将以上数据进行整理统计。结果 肝胆外科应用最多(26.1%);用量较大的主要是危重患者;在个人用量分布方面,以使用10~20 g的患者最多;用药原因以低蛋白血症所占比例最大(38.9%);使用人血清蛋白前患者血清清蛋白浓度分布主要集中在20~30 g/L范围内。结论 该院人血清蛋白的使用还存在一些问题,应遵循安全、有效、经济的用药原则,严格执行人血清蛋白的适应证,以获得最佳的效果。

Investigation and analysis on rational clinical application of human serum album in 172 cases

Objective To evaluate the clinical application of human serum albumin for inpatients and provide evidence to its rational administration in our hospital. Methods 172 cases were randomly selected from the inpatients that treated with human serum albumin during the period from January to December 2010 by Mei-Kang clinical pharmacy workstation. To get the relating clinical application information from the choosing cases which were retrospectively analyzed. A comprehensive analysis was performed on age, sex, clinical departments, diagnosis, course of treatment, reasons of use, albumin concentration before using drugs etc.Results Most dosages of human serum albumin were used in the liver and gall surgery (26.1%), mainly for critical patients and cancer, Common individual consumption quantity ranged from 10 to 20 g. Most of patients adopted this drug for hypoproteinemia (38.9%), and most of them had a baseline serum albumin level at 10~30 g/L before using human serum albumin. Conclusion The application of human albumin in our hospital was far from perfect. The principle of effective, safe, economical and rational use of drugs should be adhere to reach the best efficacy application of human albumin.