四氢-2H-1,3,5-噻二嗪-2-硫酮类化合物的合成与抗菌活性

报道10个四氢-2H-1,3,5-噻二嗪-2-硫酮类化合物的合成与体外抗菌试验,其中7个化合物为新化合物。经元素分析、紫外光谱、红外光谱及核磁共振氢谱等确证它们的结构,并试验它们对6种细菌和2种霉菌的生物活性。结果显示此类化合物的抗菌活性显著强于临床上正在使用的磺胺嘧啶钠注射液,而稍弱于诺氟沙星注射液。对革兰氏阴性菌的抑制作用强于对革兰氏阳性菌的作用,对霉菌的活性很弱。

SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF TETRAHYDRO-2H-1,3,5-THIADIAzINE-2-THIONES

Ten 3-benzyl-5-subetitued tetrahydro-2H-1,3,5-thiadiazine-2-thiones weresynthesized and seven of them are reported for the first time.The structures of the compounds havebeen elucidated by UV,IR,H-NMR and elemental analysis.The in vitro activity of the compoundsagainst 6 kinds of bacteria and 2 kinds of fungi was tested.The antimicrobial activities of allcompounds are more potent than sulfadiazine sedium and less potent than norfloxacini.All compoundswere found to be more active against gram-negative and less active against gram-positive bacteria andweak against fungi.