| 高效液相色谱法测定复方磺胺甲噁唑混悬剂的含量 |
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| 引用本文： | 丁建,朱锁年. 高效液相色谱法测定复方磺胺甲噁唑混悬剂的含量[J]. 药学与临床研究, 2003, 11(6): 28-30 |
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| 作者姓名： | 丁建 朱锁年 |
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| 作者单位： | [1]常州市药品检验所，常州213003 [2]江苏林海药业有限公司制造分公司，金坛213200 |
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| 摘 要： | 目的 采用HPLC法测定复方磺胺甲噁唑混悬剂中磺胺甲嗯唑(SMZ)和甲氧苄啶(TSW)的含量。方法 采用Zorbax SB-C18色谱柱；以磷酸盐缓冲液-乙腈(75：25)为流动相；流量为1．0ml／min；检测波长为230nm；用外标法测定。结果 平均回收率：SMZ为99．68％，RSD为0．26％；TMP为100．6％，RSD为0．76％。结论 该方法简便、准确、可靠，适用于复方磺胺甲噁唑混悬剂的定量检测。
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| 关 键 词： | HPLC 复方磺胺甲噁唑混悬剂 磺胺甲噁唑（SMZ） 甲氧苄啶（TMP） |
| 收稿时间： | 2003-04-28 |
Determination of Suspension Sulfamethoxazole Composite by HPLC |
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| Ding Jian and Zhu Suonian. Determination of Suspension Sulfamethoxazole Composite by HPLC[J]. Pharmacertical and Clinical Research, 2003, 11(6): 28-30 |
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| Authors: | Ding Jian and Zhu Suonian |
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| Abstract: | Objective To determine SMZ and TMP in Suspension Sulfam ethoxazole Composite by HPLC. Method A Zorbax SB-C18 column was used. The mobile phase was phosphoric buffer(pH 2.5,0.025 mol/L)-acetonitrile (75:25) and the flow rate was 1.0ml/min. The UV detection wavelength was 230nm. Result The average recovey was 99.7%(RSD=0.26%)and 100.6%(RSD=0.76%) for SMZ and TMP. Conclusion: The method is simple, accurate and reliable. The method was suitable for the determination of Suspension Sulfamethoxezole Composite. |
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| Keywords: | HPLC Compound SMZ oral suspension SMZ TMP |
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