Pulsed Ultrasound Remedies Post-thoracotomy Hypersensitivity and Increases Spinal Anti-inflammatory Cytokine in Rats |
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| Affiliation: | 2. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;3. Department of General Surgery, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan;4. Department of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan;5. Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan;11. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan;2. Department of Neurology, University of Regensburg, Medbo Bezirksklinikum Regensburg, Regensburg, Germany;3. Department for Vascular and Endovascular Surgery, University Clinic Regensburg, Regensburg, Germany;4. Center for Neuroradiology, Medbo Bezirksklinikum and University Clinic Regensburg, Regensburg, Germany;5. Alzheimer''s Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, California, USA;2. Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;3. Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy;4. Cruz Roja Mexicana, Estado de México Coordinación, de Capacitación Ciudad de México, México City, México |
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| Abstract: | The purpose of the experiment was to study the effect of pulsed ultrasound (PUS) on post-thoracotomy pain and local tissue temperature and to correlate the findings with the alteration in spinal anti-inflammatory and pro-inflammatory cytokines. Mechanical sensitivity, subcutaneous temperature and spinal interleukin-10 (IL-10), IL-6 or tumor necrosis factor-alpha (TNF-α) expression were examined in a rat model of experimental post-thoracotomy pain. Group 1 received a sham surgery where thoracotomy was performed except for rib retraction. Group 2 underwent thoracotomy with rib retraction (TRR). Group 3 received the TRR procedure followed by PUS. Group 4 underwent the TRR procedure followed by only the massage with the ultrasound turned off. Compared with group 1 (sham), groups 2–4 showed a decrease in mechanical withdrawal thresholds on postoperative days (PODs) 10 and 11. On PODs 16, 23 and 30, group 3 (TRR+PUS-1) displayed an increase in mechanical withdrawal thresholds compared with groups 2 and 4. Subcutaneous and body temperatures in group 3 were not prominently different from group 1, group 2 (TRR only) or group 4 (TRR+PUS-0). Compared with group 2, group 3 had an increase in spinal IL-10 level on POD 30 and a decrease in spinal IL-6 or TNF-α expression on PODs 16 and 30. We concluded that mechanical hypersensitivity after TRR is postponed by PUS, and its effect continues for 3 wk. A PUS dose not increase local tissue temperature. The beneficial effect of PUS appears related to upregulation of spinal anti-inflammatory cytokine and downregulation of spinal pro-inflammatory cytokines. |
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