Wound healing of laser injured skin with glycerol monooleicate cubic liquid crystal |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China;2. Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;3. Institute of Pharmacy, Anhui Medical University, Hefei 230032, China;4. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University Graz, Austria;2. COREMED — Centre for Regenerative Medicine, Joanneum Research Forschungsgesellschaft mbH, Graz, Austria;1. St. Andrews Unit for Burns & Plastic Surgery, Broomfield Hospital, Chelmsford, UK;2. National Burns Unit, St James’ Hospital Dublin, Ireland;1. Department of Plastic, Reconstructive & Aesthetic Surgery, Singapore General Hospital, Singapore;2. Lee Kong Chian School of Medicine, Clinical Sciences Building, Nanyang Technological University 11, Mandalay Road, 308232 Singapore;3. Skin Research Institute Singapore, Clinical Sciences Building, 11, Mandalay Road, 308232 Singapore;1. Center for Biomedical Engineering, Indian Institute of Technology Ropar, Punjab, India;2. Computer Science and Engineering, Indian Institute of Technology Ropar, Punjab, India;1. Erasmus MC, University Medical Center Rotterdam, Department of Public Health, Rotterdam, The Netherlands;2. Association of Dutch Burn Centres, Maasstad Hospital, Rotterdam, The Netherlands;3. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands;4. State Adult Burn Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia;5. Burn Injury Research Node, The University of Notre Dame, Western Australia, Australia;6. Fiona Wood Foundation, Murdoch, Western Australia, Australia |
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| Abstract: | Laser has found increasingly wider applications in the medical filed, but laser is likely to cause damage to patients’ skin. In this experiment, we were surprised to find that glyceryl monooleate (GMO)-based cubic liquid crystal had excellent healing effect on the skin of guinea pigs damaged by laser. Transepidermal water loss (TEWL), H.E. pathology, Masson trichrome dyeing, interleukin-6 (IL-6) levels and the percutaneous depth of fluorescein isothiocyanate (FITC) dyeing were used to evaluate the therapeutic effect of GMO-based cubic liquid crystals against laser damage of different degrees among guinea pigs. GMO-based cubic liquid crystals had an obvious effect in the treatment of slight and moderate laser damage. This finding may provide a effective medical treatment protocols for laser skin damage. |
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| Keywords: | Laser Glyceryl monooleate (GMO) Cubic liquid crystal Wound healing |
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