基于生物标志物探索系统性红斑狼疮中医药治疗机制的研究进展

系统性红斑狼疮（SLE）是一种多器官受累的自身免疫性疾病，目前基于糖皮质激素和免疫抑制剂的治疗，仍然存在很多局限性和个体差异。近年来，越来越多的研究表明，联合中医药治疗SLE具有疗效好，不良反应低和安全性高等优点。但是，中医药治疗SLE的确切调节机制和作用环节尚不明确，本文从代谢组学、免疫细胞、淋巴细胞因子和细胞凋亡等，对中医药治疗SLE机制的研究进行综述，为利用现代化方法探索祖国传统医学治疗SLE的机制研究提供思路。

Research progress of tradition Chinese medicine treatment mechanism of systemic lupus erythematosus based on biomarkers

Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple organ involvement. There are still many limitations and individual differences in the treatment based on glucocorticoids and immunosuppressants. In recent years, more and more studies have shown that the combination of traditional Chinese medicine in the treatment of SLE has the advantages of good efficacy, low adverse reactions, and high safety. However, the exact regulatory mechanism and combined traditional Chinese medicine in the treatment of SLE are still unclear. This paper reviews the research on the mechanism of traditional Chinese medicine in the treatment of SLE from metabonomic, immune cells, lymphocyte factors and apoptosis, etc, provides ideas for exploring the mechanism of traditional Chinese medicine in the treatment of SLE with modern methods.