Normal Age- and Sex-Related Values of the Optic Nerve Sheath Diameter and Its Dependency on Position and Positive End-Expiratory Pressure |
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| Affiliation: | 2. Department of Neurology, University of Regensburg, Medbo Bezirksklinikum Regensburg, Regensburg, Germany;3. Department for Vascular and Endovascular Surgery, University Clinic Regensburg, Regensburg, Germany;4. Center for Neuroradiology, Medbo Bezirksklinikum and University Clinic Regensburg, Regensburg, Germany;5. Alzheimer''s Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, California, USA;2. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;3. Department of General Surgery, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan;4. Department of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan;5. Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan;11. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan |
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| Abstract: | Optic nerve sheath diameter (ONSD) sonography is a reliable method for evaluation of intracranial pressure, yet there is a lack of reliable normal values. In the study described here, we established normal ONSD values in three different age groups and both sexes. One hundred eighty-seven volunteers without central nervous system disease were enrolled in this prospective study. ONSD measurements were taken in volunteers in the supine and upright positions and after application of positive end-expiratory pressure (PEEP). Normal ONSD values were 4.9–5.3 mm (patient age range: 20–85), with significant differences between men and women (p < 0.001). ONSD values increased with age (∆ = 0.34 mm, p < 0.001). There were no differences compared with the upright position but application of PEEP led to significantly increased ONSD values (∆ = 0.21 mm, p = 0.008). ONSD values increased with age, correlated well with the width of the third ventricle, were significantly lower in the female cohort and quickly responded to PEEP, especially in women. |
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