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Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts
Affiliation:1. Department of Urology, University of Washington School of Medicine, Seattle, WA, USA;2. Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;3. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;4. Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA;5. Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA;6. Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA;7. Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;8. Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China;1. Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA;2. Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA;3. Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA;1. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;2. Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;3. Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, NE, USA;4. Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, USA;5. Division of Hematology/Oncology, Columbia University Medical Center, New York, NY, USA;1. Department of Medicine, University of Washington, Seattle, WA, USA;2. Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Mailstop D4-100, 1100 Fairview Avenue N, Seattle, WA 98109-1024, USA;3. Department of Urology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA;4. Department of Pathology, University of Washington, Seattle, WA, USA;5. Memorial Sloan-Kettering Cancer Center, New York, NY, USA;6. Johns Hopkins University, Baltimore, MD, USA;7. Baylor College of Medicine, Houston, TX, USA;8. Vancouver Prostate Centre, Vancouver, BC, Canada;1. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA;2. Department of Biostatistics, Johns Hopkins School of Medicine, Baltimore, MD, USA;3. Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, USA;4. Department of Internal Medicine, Division of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE, USA;5. Department of Urology, Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
Abstract:
Keywords:Supraphysiological testosterone  Testosterone  Androgen deprivation therapy  Enzalutamide  Androgen receptor  Castration-resistant prostate cancer  Patient-derived xenografts
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